USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P14786 USC-OGP 2-DE database:  P14786 P14786 General information about the entry View entry in simple text format Entry name KPY2_HUMAN Primary accession number P14786 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Pyruvate kinase PKM; EC=2.7.1.40; AltName: Full=Cytosolic thyroid hormone-binding protein; Short=CTHBP; AltName: Full=Opa-interacting protein 3; Short=OIP-3; AltName: Full=Pyruvate kinase 2/3; AltName: Full=Pyruvate kinase muscle isozyme; AltName: Full=Thyroid hormone-binding protein 1; Short=THBP1; AltName: Full=Tumor M2-PK; AltName: Full=p58;. Gene name Name=PKM Synonyms=OIP3, PK2, PK3, PKM2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0878: pI=6.14; Mw=62229 SPOT OGP-0883: pI=7.28; Mw=58329 SPOT OGP-0885: pI=7.45; Mw=57859 SPOT OGP-0886: pI=7.80; Mw=57859 Cross-references UniProtKB/Swiss-Prot P14618; KPYM_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KPYM_HUMAN Primary accession number P14618 Secondary accession number(s) A6NFK3 B2R5N8 B3KRY0 B4DFX8 B4DUU6 P14786 Q53GK4 Q96E76 Q9BWB5 Q9UCV6 Q9UPF2 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 223) Name and origin of the protein Description RecName: Full=Pyruvate kinase PKM; EC=2.7.1.40; AltName: Full=Cytosolic thyroid hormone-binding protein; Short=CTHBP; AltName: Full=Opa-interacting protein 3; Short=OIP-3; AltName: Full=Pyruvate kinase 2/3; AltName: Full=Pyruvate kinase muscle isozyme; AltName: Full=Thyroid hormone-binding protein 1; Short=THBP1; AltName: Full=Tumor M2-PK; AltName: Full=p58; Gene name Name=PKM Synonyms=OIP3, PK2, PK3, PKM2 Encoded on Name=PKM; Synonyms=OIP3, PK2, PK3, PKM2 Keywords 3D-structure; Acetylation; Allosteric enzyme; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Glycolysis; Hydroxylation; Isopeptide bond; Kinase; Magnesium; Metal-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Potassium; Pyruvate; Reference proteome; Transferase; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M23725; AAA36449.1; -; mRNA EMBL M26252; AAA36672.1; -; mRNA EMBL X56494; CAA39849.1; -; Genomic_DNA EMBL AK092369; BAG52542.1; -; mRNA EMBL AK222927; BAD96647.1; -; mRNA EMBL AK294315; BAG57589.1; ALT_INIT; mRNA EMBL AK300800; BAG62458.1; -; mRNA EMBL AK312253; BAG35185.1; -; mRNA EMBL AY352517; AAQ15274.1; -; Genomic_DNA EMBL AC020779; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471082; EAW77884.1; -; Genomic_DNA EMBL CH471082; EAW77888.1; -; Genomic_DNA EMBL BC000481; AAH00481.3; -; mRNA EMBL BC007640; AAH07640.1; -; mRNA EMBL BC007952; AAH07952.3; -; mRNA EMBL BC012811; AAH12811.3; -; mRNA EMBL BC035198; AAH35198.1; -; mRNA EMBL AF025439; AAC39559.1; -; mRNA CCDS CCDS32284.1; -. [P14618-1]; . CCDS CCDS32285.1; -. [P14618-2]; . CCDS CCDS55972.1; -. [P14618-3]; . PIR S30038; S30038; . PIR S64635; S64635; . RefSeq NP_001193725.1; NM_001206796.2; . RefSeq NP_001193726.1; NM_001206797.2; . RefSeq NP_001193727.1; NM_001206798.2. [P14618-3]; . RefSeq NP_001193728.1; NM_001206799.1; . RefSeq NP_001303247.1; NM_001316318.1; . RefSeq NP_002645.3; NM_002654.5. [P14618-1]; . RefSeq NP_872270.1; NM_182470.3. [P14618-2]; . RefSeq NP_872271.1; NM_182471.3. [P14618-2]; . RefSeq XP_005254502.1; XM_005254445.4. [P14618-1]; . RefSeq XP_016877802.1; XM_017022313.1. [P14618-2]; . UniGene Hs.534770; -; . UniGene Hs.704299; -; . PDB 1T5A; X-ray; 2.80 A; A/B/C/D=1-531 PDB 1ZJH; X-ray; 2.20 A; A=3-531 PDB 3BJF; X-ray; 2.03 A; A/B/C/D=14-531 PDB 3BJT; X-ray; 2.50 A; A/B/C/D=2-531 PDB 3G2G; X-ray; 2.00 A; A/B/C/D=1-531 PDB 3GQY; X-ray; 1.85 A; A/B/C/D=1-531 PDB 3GR4; X-ray; 1.60 A; A/B/C/D=1-531 PDB 3H6O; X-ray; 2.00 A; A/B/C/D=1-531 PDB 3ME3; X-ray; 1.95 A; A/B/C/D=1-531 PDB 3SRD; X-ray; 2.90 A; A/B/C/D=1-531 PDB 3SRF; X-ray; 2.84 A; A/B/C/D/E/F/G/H=1-531 PDB 3SRH; X-ray; 2.60 A; A/B/C/D=1-531 PDB 3U2Z; X-ray; 2.10 A; A/B/C/D=1-531 PDB 4B2D; X-ray; 2.30 A; A/B/C/D=2-531 PDB 4FXF; X-ray; 2.55 A; A/B/C/D=1-531 PDB 4FXJ; X-ray; 2.90 A; A/B/C/D=1-531 PDB 4G1N; X-ray; 2.30 A; A/B/C/D=14-531 PDB 4JPG; X-ray; 2.33 A; A/B/C/D=1-531 PDB 4QG6; X-ray; 3.21 A; A/B/C/D=1-531 PDB 4QG8; X-ray; 2.30 A; A/B/C/D=1-531 PDB 4QG9; X-ray; 2.38 A; A/B/C/D=1-531 PDB 4QGC; X-ray; 2.30 A; A/B/C/D=1-531 PDB 4RPP; X-ray; 2.58 A; A/B/C/D=1-531 PDB 4WJ8; X-ray; 2.87 A; A/B/C/D=1-531 PDB 4YJ5; X-ray; 2.41 A; A/B/C/D=14-531 PDBsum 1T5A; -; . PDBsum 1ZJH; -; . PDBsum 3BJF; -; . PDBsum 3BJT; -; . PDBsum 3G2G; -; . PDBsum 3GQY; -; . PDBsum 3GR4; -; . PDBsum 3H6O; -; . PDBsum 3ME3; -; . PDBsum 3SRD; -; . PDBsum 3SRF; -; . PDBsum 3SRH; -; . PDBsum 3U2Z; -; . PDBsum 4B2D; -; . PDBsum 4FXF; -; . PDBsum 4FXJ; -; . PDBsum 4G1N; -; . PDBsum 4JPG; -; . PDBsum 4QG6; -; . PDBsum 4QG8; -; . PDBsum 4QG9; -; . PDBsum 4QGC; -; . PDBsum 4RPP; -; . PDBsum 4WJ8; -; . PDBsum 4YJ5; -; . ProteinModelPortal P14618; -; . SMR P14618; -; . BioGrid 111332; 178; . DIP DIP-31273N; -; . IntAct P14618; 242; . MINT MINT-4998892; -; . STRING 9606.ENSP00000320171; -; . BindingDB P14618; -; . ChEMBL CHEMBL1075189; -; . DrugBank DB02726; 2-Phosphoglycolic Acid; . DrugBank DB01733; L-Phospholactate; . DrugBank DB00119; Pyruvic acid; . iPTMnet P14618; -; . PhosphoSitePlus P14618; -; . SwissPalm P14618; -; . BioMuta PKM; -; . DMDM 20178296; -; . DOSAC-COBS-2DPAGE P14618; -; . OGP P14618; -; . REPRODUCTION-2DPAGE IPI00220644; -; . REPRODUCTION-2DPAGE IPI00479186; -; . UCD-2DPAGE P14618; -; . EPD P14618; -; . PaxDb P14618; -; . PeptideAtlas P14618; -; . PRIDE P14618; -; . TopDownProteomics P14618-1; -. [P14618-1]; . TopDownProteomics P14618-2; -. [P14618-2]; . DNASU 5315; -; . Ensembl ENST00000319622; ENSP00000320171; ENSG00000067225. [P14618-2]; . Ensembl ENST00000335181; ENSP00000334983; ENSG00000067225. [P14618-1]; . Ensembl ENST00000449901; ENSP00000403365; ENSG00000067225. [P14618-3]; . Ensembl ENST00000565154; ENSP00000455901; ENSG00000067225. [P14618-2]; . Ensembl ENST00000565184; ENSP00000455736; ENSG00000067225. [P14618-2]; . Ensembl ENST00000568459; ENSP00000456970; ENSG00000067225. [P14618-2]; . GeneID 5315; -; . KEGG hsa:5315; -; . UCSC uc002atw.2; human. [P14618-1]; . CTD 5315; -; . DisGeNET 5315; -; . GeneCards PKM; -; . HGNC HGNC:9021; PKM; . HPA CAB019421; -; . HPA HPA029501; -; . MalaCards PKM; -; . MIM 179050; gene; . neXtProt NX_P14618; -; . OpenTargets ENSG00000067225; -; . PharmGKB PA33353; -; . eggNOG KOG2323; Eukaryota; . eggNOG COG0469; LUCA; . GeneTree ENSGT00390000008859; -; . HOGENOM HOG000021559; -; . HOVERGEN HBG000941; -; . InParanoid P14618; -; . KO K00873; -; . OMA KQHGGEH; -; . PhylomeDB P14618; -; . TreeFam TF300390; -; . BioCyc MetaCyc:HS00906-MONOMER; -; . BRENDA 2.7.1.40; 2681; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-70171; Glycolysis; . SABIO-RK P14618; -; . SIGNOR P14618; -; . UniPathway UPA00109; UER00188; . EvolutionaryTrace P14618; -; . GeneWiki PKM2; -; . GenomeRNAi 5315; -; . PRO PR:P14618; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000067225; -; . CleanEx HS_PKM2; -; . ExpressionAtlas P14618; baseline and differential; . Genevisible P14618; HS; . GO GO:0005929; C:cilium; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; NAS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1903561; C:extracellular vesicle; IDA:UniProtKB; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0043531; F:ADP binding; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0016301; F:kinase activity; IEA:UniProtKB-KW; . GO GO:0000287; F:magnesium ion binding; IEA:InterPro; . GO GO:0023026; F:MHC class II protein complex binding; IDA:UniProtKB; . GO GO:0030955; F:potassium ion binding; IEA:InterPro; . GO GO:0004743; F:pyruvate kinase activity; TAS:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0031100; P:animal organ regeneration; IEA:Ensembl; . GO GO:0006754; P:ATP biosynthetic process; IEA:Ensembl; . GO GO:0061621; P:canonical glycolysis; TAS:Reactome; . GO GO:0032869; P:cellular response to insulin stimulus; IBA:GO_Central; . GO GO:0001889; P:liver development; IEA:Ensembl; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0012501; P:programmed cell death; IDA:UniProtKB; . GO GO:0042866; P:pyruvate biosynthetic process; IEA:Ensembl; . GO GO:0009629; P:response to gravity; IEA:Ensembl; . GO GO:0001666; P:response to hypoxia; IEA:Ensembl; . GO GO:0014870; P:response to muscle inactivity; IEA:Ensembl; . GO GO:0007584; P:response to nutrient; IEA:Ensembl; . GO GO:0043403; P:skeletal muscle tissue regeneration; IEA:Ensembl; . CDD cd00288; Pyruvate_Kinase; 1; . Gene3D 2.40.33.10; -; 1; . Gene3D 3.20.20.60; -; 2; . Gene3D 3.40.1380.20; -; 1; . InterPro IPR001697; Pyr_Knase; . InterPro IPR015813; Pyrv/PenolPyrv_Kinase-like_dom; . InterPro IPR011037; Pyrv_Knase-like_insert_dom; . InterPro IPR015794; Pyrv_Knase_a/b; . InterPro IPR018209; Pyrv_Knase_AS; . InterPro IPR015793; Pyrv_Knase_brl; . InterPro IPR015795; Pyrv_Knase_C; . InterPro IPR015806; Pyrv_Knase_insert_dom; . PANTHER PTHR11817; PTHR11817; 1; . Pfam PF00224; PK; 1; . Pfam PF02887; PK_C; 1; . PRINTS PR01050; PYRUVTKNASE; . SUPFAM SSF50800; SSF50800; 1; . SUPFAM SSF51621; SSF51621; 2; . SUPFAM SSF52935; SSF52935; 1; . TIGRFAMs TIGR01064; pyruv_kin; 1; . PROSITE PS00110; PYRUVATE_KINASE; 1; .

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